Intergender wrestling is a very controversial topic. However, WWE was slowly warming up to the idea by testing the waters back in the Royal Rumble, as Nia Jax took part in the Men’s Royal Rumble. However, they dropped the idea of intergender wrestling when they nixed the advertised match between Dean Ambrose and Nia Jax.
The Wrestling Observer Newsletter mentioned that WWE also had plans for a Randy Orton vs Nia Jax match. This was already teased during their interaction at the Royal Rumble, where Orton gave Jax an RKO for good measure.
It seems that something happened that change Vince McMahon’s mind and it seems to have been Triple H who has been openly against that kind of match.
Vince McMahon himself was at one point interested [in intergender wrestling] and then changed his mind. Paul Levesque has been publicly negative on them and hasn’t done them in NXT either.
Perhaps WWE will eventually embrace the idea of intergender wrestling in 2019. After all, many female talents are more than ready for that kind of matchup. We will have to wait until then.